Multidimensional Simulations of Rotating Pair Instability Supernovae

We study the effects of rotation on the dynamics, energetics and Ni-56 production of Pair Instability Supernova explosions by performing rotating two-dimensional ("2.5-D") hydrodynamics simulations. We calculate the evolution of eight low metallicity (Z = 10^-3, 10^-4 Zsun) massive (135-245 Msun) PISN progenitors with initial surface rotational velocities 50% that of the critical Keplerian value using the stellar evolution code MESA. We allow for both the inclusion and the omission of the effects of magnetic fields in the angular momentum transport and in chemical mixing, resulting in slowly-rotating and rapidly-rotating final carbon-oxygen cores, respectively. Increased rotation for carbon-oxygen cores of the same mass and chemical stratification leads to less energetic PISN explosions that produce smaller amounts of Ni-56 due to the effect of the angular momentum barrier that develops and slows the dynamical collapse. We find a non-monotonic dependence of Ni-56 production on rotational velocity in situations when smoother composition gradients form at the outer edge of the rotating cores. In these cases, the PISN energetics are determined by the competition of two factors: the extent of chemical mixing in the outer layers of the core due to the effects of rotation in the progenitor evolution and the development of angular momentum support against collapse. Our 2.5-D PISN simulations with rotation are the first presented in the literature. They reveal hydrodynamic instabilities in several regions of the exploding star and increased explosion asymmetries with higher core rotational velocity.Comment: 31 pages, 23 figures, accepted for publication in the Ap

Three-Dimensional Gravity and String Ghosts

It is known that much of the structure of string theory can be derived from three-dimensional topological field theory and gravity. We show here that, at least for simple topologies, the string diffeomorphism ghosts can also be explained in terms of three-dimensional physics.Comment: 6 page

Phase field modeling of electrochemistry II: Kinetics

The kinetic behavior of a phase field model of electrochemistry is explored for advancing (electrodeposition) and receding (electrodissolution) conditions in one dimension. We described the equilibrium behavior of this model in [J. E. Guyer, W. J. Boettinger, J.A. Warren, and G. B. McFadden, ``Phase field modeling of electrochemistry I: Equilibrium'', cond-mat/0308173]. We examine the relationship between the parameters of the phase field method and the more typical parameters of electrochemistry. We demonstrate ohmic conduction in the electrode and ionic conduction in the electrolyte. We find that, despite making simple, linear dynamic postulates, we obtain the nonlinear relationship between current and overpotential predicted by the classical ``Butler-Volmer'' equation and observed in electrochemical experiments. The charge distribution in the interfacial double layer changes with the passage of current and, at sufficiently high currents, we find that the diffusion limited deposition of a more noble cation leads to alloy deposition with less noble species.Comment: v3: To be published in Phys. Rev. E v2: Attempt to work around turnpage bug. Replaced color Fig. 4a with grayscale 13 pages, 7 figures in 10 files, REVTeX 4, SIunits.sty, follows cond-mat/030817

Genetic and environmental variation impact transferability of polygenic risk scores

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment

A Review and Look Ahead at Criminalizing Pregnancy in the Name of State Interest in Fetal Life

Across the United States, and especially in communities that are highly policed and in places hostile to abortion, pregnant people are dying, suffering, being separated from their children and families, and going to jail and prison in purported service of the state interest in fetal life recognized in Roe v. Wade and expanded in Planned Parenthood of Pennsylvania v. Casey. This Article focuses on two common practices that cause these harms: criminalizing pregnant people and denying them medical decision-making authority. While these practices are not new, the U.S. Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization is accelerating them. With abortion returned to the states without a U.S. constitutional floor, the state interest in fetal life can go largely unchecked with respect to all pregnant people, not just those who need abortions. In this Article, we look back at several cases from the 1990s and early 2000s involving denials of medical decision-making authority and criminalization of pregnant people for substance use during pregnancy. We also discuss contemporary instances of these phenomenon, focusing on Alabama’s Child Chemical Endangerment Act and 1997 Wisconsin Act 292, both of which are currently and fervently used to punish pregnant people for actual or suspected substance use and which fail entirely to advance fetal or parental well-being. Based on our survey of these past and present cases, we reflect on several legal arguments and strategies to demand and restore full personhood for pregnant people. We link pregnancy criminalization to legally cognizable animus, observing that hallmark features of such animus abound when substance use during pregnancy is criminalized. We link environmental injustice to pregnancy criminalization, observing that it is irrational to punish and jail people for “polluting” the micro-environment of the womb in service of an interest in fetal life when all people—particularly the most policed—are perniciously, macro-environmentally exposed to toxins that impact reproduction and pregnancy. We reiterate that informed consent to medical treatment is the bedrock guarantee of healthcare and bodily autonomy—and pregnancy demands rather than diminishes this guarantee—and that drug tests without consent that lead to law enforcement consequences violate both this and the Fourth Amendment. We also very briefly emphasize that mandatory reporting of suspected child abuse or neglect based on a positive drug test fails to protect anyone and that mandatory reporters can challenge this obligation where it frustrates core professional duties. Together, all of these threads intersect to show that criminalizing pregnancy and denying pregnant people medical decision-making authority is about the social control and exclusion that punishment accomplishes. The impulse to control and exclude surely varies intersectionally, corresponding to the expectations and stereotypes about parenting applicable to the punished person or community. But in the end, in every case, no fetal life, no parental life, no family life, and no constitutional right or medical objective is protected or furthered when pregnancy is criminalized and pregnant people are denied medical decision-making authority

Quantum gravity and the Coulomb potential

We apply a singularity resolution technique utilized in loop quantum gravity to the polymer representation of quantum mechanics on R with the singular -1/|x| potential. On an equispaced lattice, the resulting eigenvalue problem is identical to a finite difference approximation of the Schrodinger equation. We find numerically that the antisymmetric sector has an energy spectrum that converges to the usual Coulomb spectrum as the lattice spacing is reduced. For the symmetric sector, in contrast, the effect of the lattice spacing is similar to that of a continuum self-adjointness boundary condition at x=0, and its effect on the ground state is significant even if the spacing is much below the Bohr radius. Boundary conditions at the singularity thus have a significant effect on the polymer quantization spectrum even after the singularity has been regularized.Comment: 10 pages, 5 figures. v2: Minor presentational changes. One data point added in Table

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD

The Convective Urca Process with Implicit Two-Dimensional Hydrodynamics

Consideration of the role of the convective flux in the thermodymics of the convective Urca neutrino loss process in degenerate, convective, quasi-static, carbon-burning cores shows that the convective Urca process slows down the convective current around the Urca-shell, but, unlike the "thermal" Urca process, does not reduce the entropy or temperature for a given convective volume. Here we demonstrate these effects with two-dimensional numerical hydrodynamical calculations. These two-dimensional implicit hydrodynamics calculations invoke an artificial speeding up of the nuclear and weak rates. They should thus be regarded as indicative, but still qualitative. We find that, compared to a case with no Urca-active nuclei, the case with Urca effects leads to a higher entropy in the convective core because the energy released by nuclear burning is confined to a smaller volume by the effective boundary at the Urca shell. All else being equal, this will tend to accelerate the progression to dynamical runaway. We discuss the open issues regarding the impact of the convective Urca process on the evolution to the "smoldering phase" and then to dynamical runaway.Comment: 22 pages, 11 figures, accepted for publication in the Astrophysical Journa

Apparent horizons in simplicial Brill wave initial data

We construct initial data for a particular class of Brill wave metrics using Regge calculus, and compare the results to a corresponding continuum solution, finding excellent agreement. We then search for trapped surfaces in both sets of initial data, and provide an independent verification of the existence of an apparent horizon once a critical gravitational wave amplitude is passed. Our estimate of this critical value, using both the Regge and continuum solutions, supports other recent findings.Comment: 7 pages, 6 EPS figures, LaTeX 2e. Submitted to Class. Quant. Gra

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake

Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to produce a synergistic effect on reward circuitry. This effect is also observed when the stress hormone corticosterone is administered directly into the nucleus accumbens (NAc), indicating that glucocorticoids act locally in dopamine terminal regions to enhance cocaine\u27s effects on dopamine signaling. However, prior studies in behaving animals have not provided mechanistic insight. Using fast‐scan cyclic voltammetry, we examined the effect of systemic corticosterone on spontaneous dopamine release events (transients) in the NAc core and shell in behaving rats. A physiologically relevant systemic injection of corticosterone (2 mg/kg i.p.) induced an increase in dopamine transient amplitude and duration (both voltammetric measures sensitive to decreases in dopamine clearance), but had no effect on the frequency of transient release events. This effect was compounded by cocaine (2.5 mg/kg i.p.). However, a second experiment indicated that the same injection of corticosterone had no detectable effect on the dopaminergic encoding of a palatable natural reward (saccharin). Taken together, these results suggest that corticosterone interferes with naturally occurring dopamine uptake locally, and this effect is a critical determinant of dopamine concentration specifically in situations in which the dopamine transporter is pharmacologically blocked by cocaine